T J Clark’s Advanced CoQ10 Formula provides 50mg of highly absorbable coenzyme Q10 with the addition of the antioxidants vitamin C and E for nerve, cardiac and white blood cell protection. Our advanced formula utilises the latest technology in CoQ10 manufacturing and delivery, incorporating the specific fatty acids from rice bran oil to enhance absorption. The oil base used for this product has been shown to enhance absorption by approximately 273% over non-oil based presentation (tablets, capsules and other oil based preparations), resulting in highly effective blood levels.
Purified water, Natural cane sugar, Rice bran oil, N & A Flavor, Potassium Sorbate (0.1%)
Pharmacology and Research of Active Ingredients:
Supplemental CoQ10 is typically derived from tobacco leaf extracts and fermented sugar cane and beets. CoQ10 is an essential cofactor in the mitochondrial electron transport chain, where it accepts electrons from complex I and II, an activity that is vital for the production of ATP. CoQ10 has antioxidant activity in mitochondria and cellular membranes, protecting against peroxidation of lipid membranes. It also inhibits the oxidation of LDL-cholesterol. LDL-cholesterol oxidation is believed to play a significant role in the pathogenesis of atherosclerosis.
Tissues with high energy turnover (nerve, cardiac muscle and white blood cells) require a high saturation of CoQ10. CoQ10 is biosynthesized in the body and shares a common synthetic pathway with cholesterol. CoQ10 levels decrease with aging in humans. Why this occurs is not known but may be due to decreased synthesis and/or increased lipid peroxidation which occurs with aging.
Supplemental CoQ10 is indicated wherever oxygen utilisation and cellular energy production is sub-optimal. This becomes more important in conditions associated with chronic hypoxia and mitochondrial dysfunction.
There are many studies, spanning more than two decades, reporting positive results from the use of CoQ10 as adjunctive therapy in the treatment of congestive heart failure. CoQ10 has been an approved drug in Japan for use in congestive heart failure since 1974. It has also been approved for this use in some other countries. Several studies have demonstrated a strong correlation between severity of heart disease and severity of CoQ10 deficiency. Some have suggested that this deficiency is the primary cause of some variations of heart muscle dysfunction, while others believe it plays a secondary role in the etiology of heart failure.
Clinical reports from Japan suggest that supplemental CoQ10 may improve beta-cell function and glycaemic control in type II diabetics. CoQ10 does not appear to improve glycaemic control in type I diabetics.
Yamagami and coworkers identified deficiencies in CoQ10 enzyme activity in the leucocytes of 45 patients with known chronic hypertension. Treatment with CoQ10 (60 mg/day for 8 weeks) produced a significant decrease in blood pressure in the group as a whole, and 54% of the patients had a mean systolic blood pressure fall of greater than 10%. Whether CoQ10 deficiency is a cause or effect of hypertension, correction of this deficiency may improve blood pressure control in selected patients.
The process of healing and tissue repair and the production of the protective gastric mucus are highly energy dependent and therefore require the presence of adequate amounts CoQ10. The hypoxic state of gastric tissue, due to cell type changes and reduced vascular supply in advancing age, may explain why gastric ulcers frequently become intractable in elderly patients or in individuals with chronic heart or lung disease. CoQ10 administration to mice with gastric ulcers (kept under mild hypoxic conditions (17% oxygen)) prevented the adverse effect of hypoxia on gastric ulcer healing.
Double-blind studies with CoQ10 on patients with both acute and chronic cerebral apoplexy showed a significant improvement in mental disturbances, lower extremity performance and overall symptom picture. Clinical studies conducted with oral CoQ10 at dosage levels of 30-45 mg/day showed that CoQ10 had a beneficial effect on subjective symptoms or nervous signs in patients with cephalotrauma, sequela, and cerebrovascular performances.
Cardiac side effects frequently occur from the use of certain psychotropic drugs, including phenothiazines and tricyclic antidepressants. The cardiotoxicity of these drugs is caused by inhibition of CoQ10 dependent enzymes resulting in impaired respiration in myocardial cells. In two clinical studies, CoQ10 supplementation ameliorated electrocardiographic changes in patients on psychotropic drugs.
Recent studies using high dose CoQ10 in patients with high-risk breast cancer have demonstrated some promising results. Thirty-two patients were treated with 90 mg of CoQ10, antioxidants and fatty acids. Six of these high-risk patients showed partial tumour regression. In one of these 6 cases, the dosage of CoQ10 was increased to 390 mg and after one month the tumour was no longer palpable. Within another month, mammography confirmed absence of the tumour. Encouraged by this result, another patient was put on 300 mg per day and within 3 months there was no residual tumour.
Vitamin C is an antioxidant and therefore aids in the protection of the immune system by metabolising and detoxifying a wide range of pollutants and chemicals. Vitamin C acts as a detoxifying agent by blocking the conversion of nitrates to nitrosamines and nitrous amides in the stomach, reducing the risk of stomach carcinogenesis. White blood cells contain high amounts of vitamin C and research has shown that it enhances human T-lymphocyte activity and enhances the mobility of phagocytic cells. Further, vitamin C has been shown to increase immunoglobulin biosynthesis and promote B-cell antibody formation, while supplementation with CoQ10 has shown to benefit cardiovascular disease and the immune system.
Numerous epidemiological studies have associated higher vitamin E status with reduced cancer, including lung, colorectal, prostate, colon, stomach, reproductive organs, upper gastrointestinal tract, bladder, breast, cervix, mouth, pharynx and thyroid cancer. Reduced serum vitamin E levels are also associated with a higher incidence of lymphoma and leukaemia in some populations. Vitamin E improves cellular respiration, enhances the immune system, regulates the central nervous system, provides antioxidant protection, and acts as a detoxifier.
Rice bran oil provides a unique array of fatty acids which have been shown to increase the uptake of CoQ10 by up to 273%. Please ask for our technical sheet entitled “CoQ10 Stability” for further information.
T J Clark’s Advanced CoQ10 Formula may be beneficial in the prevention and treatment of;
Aids or HIV, athletes, breast metastasis, cardiomyopathy, chemotherapy, diabetes, beta blocker medication and gastric ulcers.
Angina, congestive heart failure, hypertension, hyperthyroid, infections and lung disease.
Mitral valve prolapse, muscular dystrophy, obesity, periodontal disease, and the elderly.
There is one report of CoQ10 decreasing the effectiveness of warfarin. Those taking warfarin should be aware of this possibility.
Individuals on warfarin should be cautious in using high doses of vitamin E (i.e., doses greater than 100 milligrams daily of d-alpha-tocopherol or 200 milligrams daily of dl-alpha-tocopherol), and if they do use such doses, they should have their INRs monitored and their warfarin dose appropriately adjusted if indicated. Vitamin E should not be taken 7 days before any surgery.
Contents: 237ml Storage: Store below 30 C Dosage and Administration: 8ml once or twice daily with food
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