L - Carnitine
L-carnitine, an amino acid derivative, is found in nearly all cells of the body. L-carnitine transports long-chain fatty acids across the inner mitochondrial membranes in the mitochondria, where they are processed by beta-oxidation to produce biological energy in the form of adenosine triphosphate or ATP. Therapeutically L-Carnitine has been shown to be effective in treating heart disease, myopathy, hyperlipidaemias and alcoholism. Our L-Carnitine is flavoured with fructose to improve patient compliance and is catalyzed with the T J Clark phytogenic mineral catalyst for superior bioavailability.
Each 8ml contains
Phytogenic Mineral Catalyst
(Containing but not limited to B, Ca, Cr, Co, Cu, I, Fe, Li, Mg, Mn, Mo, P, K, Se, Si, Sr, V, Zn)
Purified water, Organic Organic Fruit Punch Flavor, Natural Cane Sugar, Potassium Sorbate (0.1%)
Pharmacology and Research of Active Ingredients:
- L-carnitine is also known as levocarnitine and was formerly called vitamin BT. L-carnitine is a quarternary amine and belongs to the same chemical family as choline and is soluble in water. L-carnitine is synthesized in the human body, chiefly in the liver and kidneys, from the essential amino acids L-lysine and L-methionine. Niacin, vitamins B6 and C, and iron are involved in its biosynthesis.
- In cardiac and skeletal muscle, a major contribution of bio energy comes from the beta-oxidation of long-chain fatty acids. Long-chain fatty acids require L-carnitine to transport them across the inner membranes of the mitochondria, wherein their metabolism produces bio energy. Following the delivery of long-chain fatty acids into other mitochondria, L-carnitine, either by itself or esterified to an acyl group, recrosses the mitochondrial membrane to allow for continual use in this shuttle process. Another function of L-carnitine is to remove short-chain and medium-chain fatty acids from the mitochondria in order to maintain coenzyme A levels in these organelles. These fatty acids accumulate as a result of normal and abnormal metabolism. This mechanism prevents the build-up in the mitochondria of short-chain and medium-chain fatty acids that may interfere with the bio energy-producing process vital to the normal function of the cell.
- L-carnitine may possess antioxidant properties. A disturbance in long-chain fatty acid oxidation in mitochondria and/or the accumulation of small-chain and medium-chain fatty acyl CoA molecules in the mitochondria might be expected to increase oxidative stress. There is some evidence that proprionyl-L-carnitine, a delivery form of L-carnitine, might protect the ischemic heart from reperfusion injury via an antioxidant effect.
- Carnitine is able to protect cardiac muscle against hypoxic injury due to poor blood flow (coronary artery disease) and thrombosis. By improving cardiac muscle bioenergetics carnitine is preserving cell function. Research demonstrates this role of carnitine in experimental ischaemia in animals. When blood flow returns to the heart muscle, it was found to resume normal function more quickly when carnitine had been given previously.
- Deficiencies in carnitine are known to be associated with congestive heart failure. Supplementation with carnitine has also shown benefit in these patients. Recent research found acute administration of carnitine increased peak oxygen consumption by 45%, increases exercise time by 21%, and increased peak exercise heart rate by 12% in 30 patients with chronic congestive heart failure. This randomised placebo-controlled study also found a reduction in pulmonary artery pressure and left ventricular mass.
- Carnitine deficiency may arise due to haemodialysis, medication (Valporic acid, Adriamycin, Zibovudine, Cefteran, Pivoxil) renal failure, ageing, diabetes, celiac disease and AIDS. All of these conditions result in poor energy production resulting in symptoms of myopathy, cardiomyopathy, acidurias, hyperlipoprotenaemia, poor energy or fatigue.
- Phytogenic Mineral Catalyst – Our Polyfloramin™extracts contain up to 72 trace elements for enhanced bioavailability, assimilation and synergy of the active ingredients contained in our Carnitine formula.
T J Clark’s Carnitine formula may be beneficial in the prevention and treatment of;
- Angina, AIDS, asthma, cirrhosis, cancer cachexia, celiac disease, congestive heart failure, cystic fibrosis, diabetes, diphtheria, emphysema, fatigue and inflammatory myopathies.
- Ischemia, ketosis, kidney disease, muscular dystrophy, myocardial infarction, obesity, poor circulation, Rett’s syndrome, ventricular fibrillation.
Storage: Store below 30 C
Dosage and Administration: 8ml once or twice daily with food.