Molybdenum is an essential trace mineral in plant, animal and human nutrition. It is found in several tissues of the human body and is required for the activity of three important enzyme systems, xanthine oxidase, aldehyde dehydrogenase and sulfite oxidase—and so has a vital role in uric acid formation, iron utilization and the catabolism of purines and the sulfur amino acids. T J Clark’s Catalyzed Molybdenum contains a highly bioavailable colloidal form of molybdenum. Catalyzed Molybdenum is flavoured with fructose for greater patient compliance. Our phytogenic mineral catalyst is included for maximum nutrient utilisation.
Each 5ml contains
Phytogenic Mineral Catalyst
(Containing but not limited to B, Ca, Cr, Co, Cu, I, Fe, Li, Mg, Mn, Mo, P, K, Se, Si, Sr, V, Zn)
Purified water, Organic Vanilla Flavor, Natural Cane Sugar, Potassium Sorbate (0.1%)
Pharmacology and Research of Active Ingredients:
- The active biological form of molybdenum is known as the molybdenum cofactor or Moco. Moco is the cofactor for four human enzymes: xanthine dehydrogenase (xanthine: NAD+ oxidoreductase), xanthine oxidase (a form of xanthine dehydrogenase), sulfite oxidase (sulfite dehydrogenase; sulfite: ferricytochrome c oxidoreductase), and aldehyde oxidase (aldehyde: oxygen oxidoreductase). Xanthine dehydrogenase catalyzes the conversion of hypoxanthine to xanthine, and xanthine to uric acid. In addition to uric acid, the end product of purine catabolism, NADH is formed from NAD+ in the reaction. Xanthine oxidase also catalyzes the reactions of purine end metabolism.
- Sulfite oxidase is involved in the degradative metabolism of the sulfur amino acids methionine and cysteine. Sulfite oxidase, which is located in mitochondria, converts sulfite to sulfate. Sulfite is derived from the metabolism of cysteine. Aldehyde oxidase is involved in a number of reactions, including the catabolism of pyrimidines and the biotransformation of xenobiotics. In the soil and possibly in the body, as the enzyme nitrate reductase, molybdenum can reduce the production or counteract the actions of nitrosamines, known cancer-causing chemicals, especially in the colon. Found more in molybdenum-deficient soils, nitrosamines have been associated with high rates of oesophageal cancer.
- Lin Xian is a small region in Honan Province in north China which has had one of the highest incidences of oesophageal cancer in the world. It was determined that the soil in this area was markedly low in molybdenum. In order for nitrates in the soil to be reduced to nitrogenous substances necessary for plant nutrition, a molybdenum-dependent enzyme, nitrate reductase (found in nitrogen-fixing bacteria), is required. When the molybdenum level in the soil is low, instead of being converted to amines, the nitrates get converted to nitrosamines, known carcinogenic substances.
By enriching the soil with molybdenum, as ammonium molybdate, those living in this region are exposed to lower amounts of nitrosamines in their diets, and the incidence of oesophageal cancer is be declining.
- Phytogenic Mineral Catalyst – Our Polyfloramin™extracts contain up to 72 trace elements for enhanced bioavailability, assimilation and synergy of the active ingredients contained in our Molybdenum formula.
T J Clark’s Catalysed Molybdenum formula may be beneficial in the prevention and treatment of:
- Asthma susceptibility, defective sulphur amino acid metabolism, dental caries, gout, increased susceptibility to sulphite toxicity, mental disturbance.
- Exposure to pollutants, anti-carcinogenic, metabisulphite sensitivity.
- Doses of molybdenum of 10 to 15 milligrams daily have been associated with a gout-like syndrome and hyperuricemia. Supplementary doses of molybdenum of up to 500 micrograms are generally well tolerated.
- High doses of molybdate may antagonize the absorption of copper. Likewise, high doses of copper may antagonize the absorption of molybdenum and overall decrease molybdenum status.
Storage: Store below 30 C
Dosage and Administration: 5ml once or twice daily with food.