Selenium has antioxidant activity. Selenium may also have immunomodulatory, anticarcinogenic and anti-atherogenic activities. It may have activity in detoxification of some metals and other xenobiotics and activity in fertility enhancement in males. Selenium enters the food chain through incorporation into plant proteins as the amino acids L-selenocysteine and L-selenomethionine. T J Clark’s Catalyzed Selenium contains the most bioavailable form of selenium, L-selenomethionine. Catalyzed selenium is flavoured with fructose for greater patient compliance. Our phytogenic mineral catalyst is included for maximum nutrient utilisation and antioxidant protection.
Each 5ml contains
|Elemental Selenium (as L-selenomethionate)
Phytogenic Mineral Catalyst
(Containing but not limited to B, Ca, Cr, Co, Cu, I, Fe, Li, Mg, Mn, Mo, P, K, Se, Si, Sr, V, Zn)
Purified water, Natural Cane Sugar, Organic Vanilla Flavor, Potassium Sorbate (0.1%)
Pharmacology and Research of Active Ingredients:
- Selenium is found in human and animal tissues as L-selenomethionine or L-selenocysteine. L-selenomethionine is incorporated randomly in proteins in place of L-methionine. The selenoproteins are comprised of four selenium-dependent glutathione peroxidases (GSHPx-1, GSHPx-2, GSHPx-3 and GSHPx-4), three selenium-dependent iodothyronine deiodinases, three thioredoxin reductases, selenoprotein P, selenoprotein W and selenophosphate synthetase. The glutathione peroxidases, and possibly selenoprotein P and selenoprotein W, are antioxidant proteins. The selenium-dependent iodothyronine deiodinases convert thyroxine to triiodothyronine, thus regulating thyroid hormone metabolism.
- Selenium deficiency appears to depress the effectiveness of various components of the immune system. In humans, selenium deficiency has been associated with depressed IgG and IgM antibody titres. In animal models, selenium deficiency has resulted in depressed neutrophil activity, decreased candidacidal activity by neutrophils and depressed cellular immunity. Selenium supplementation in humans has resulted in increased natural killer cell activity. The possible immunomodulatory effects of selenium are not well understood. Selenium's antioxidant activity may play some role, perhaps a major one, in these possible effects. It is postulated that selenium's possible effect on boosting cellular immunity may be due to upregulation of the expression of the T-cell high-affinity interleukin (IL)-2 receptor, providing a vehicle for enhanced T-cell responses, as well as prevention of oxidative-stress-induced damage to immune cells. Enhanced cellular immunity may explain the possible stimulatory effects of selenium on antibody production.
- The possible anticarcinogenic activity of selenium may be accounted, for, in part, by its antioxidant activity as well as its possible immune-enhancing activity. Selenium has been shown to upregulate apoptosis in tumour cells in vitro and increase macrophage killing and protect against oxidative DNA damage, again, in vitro.
- Some epidemiological studies have shown an inverse relationship between coronary heart disease and selenium intake. The possible anti-atherogenic activity of selenium may be accounted for, in part, by its antioxidant activity. Glutathione peroxidase may protect low density lipoprotein (LDL) from oxidation. Oxidized-LDL is thought to be a crucial etiological factor in atherogenesis. Selenium may decrease platelet aggregation. Selenium deficiency results in lipoperoxide accumulation. Lipoperoxides impair prostacyclin synthesis and promote thromboxane synthesis, which can increase platelet aggregation leading to cardiovascular disease.
- Selenium has been demonstrated to antagonize the effects of a number of toxic metals, including cadmium and arsenic. Selenium inhibits the growth stimulatory effect of cadmium on human prostatic epithelium in vitro. The mechanism of the possible antagonistic action of selenium against various toxic metals and other xenobiotics is unclear. One possibility is that it forms inactive complexes with these substances.
- Phytogenic Mineral Catalyst – Our Polyfloramin™extracts contain up to 72 trace elements for enhanced bioavailability, assimilation and synergy of the active ingredients contained in our Selenium formula.
T J Clark’s Selenium formula may be beneficial in the prevention and treatment of;
- Adenocarcinoma, ageing, alcoholism, angina, cadmium poisoning, cancer, cystic fibrosis, heart disease, and high blood pressure.
- Hypothyroidism, liver disease, Parkinson’s disease, retinal damage in diabetics, hypercholesterolemia, viral infections, muscle degeneration, and sterility in males.
- Prostate, lung, skin, and colorectal cancers.
- Intakes of selenium less than 800 micrograms daily (for adults) are unlikely to cause adverse reactions. Prolonged intakes of selenium of doses of 1,000 micrograms (or one milligram) or greater daily may cause adverse reactions.
- There are no known interactions with drugs in clinical practice.
Storage: Store below 30 C
Dosage and Administration: 5ml once or twice daily with food.