Vitamin B12 & Folic Acid
T J Clark’s catalysed vitamin B12 and folic acid is formulated as a blood tonic and can assist with the maintenance of peripheral circulation. Inflammatory gastric and intestinal disorders in addition to liver dysfunction are common causes of vitamin B12/folate (folic acid) malabsorption and poor tissue delivery. Many tissues are affected by sub clinical deficiency of B12 and folate before the presence of the classical indication of clinical deficiency, macrocytic anaemia. Taken daily for 1-4 months before conception and during pregnancy, our catalysed formula may reduce the risk of neural tube defects.
Each 8ml contains
Folate (Folic Acid)
Phytogenic Mineral Catalyst
(Containing but not limited to B, Ca, Cr, Co, Cu, I, Fe, Li, Mg, Mn, Mo, P, K, Se, Si, Sr, V, Zn)
Purified water, Organic vanilla flavours, Potassium Sorbate (0.1%)
Pharmacology and Research of Active Ingredients:
- Vitamin B12 works in close partnership with folate in the synthesis of the building blocks for DNA and RNA synthesis as well as the synthesis of molecules important for the maintenance of the integrity of the genome. It is also essential for the maintenance of the integrity of the nervous system and for the synthesis of molecules which are involved in fatty acid biosynthesis and the production of energy.
- The hematologic symptoms and signs of B12 deficiency, include hyper segmentation of polymorphonuclear leukocytes, macrocytic, hyperchromic erythrocytes, elevated mean corpuscular volume (MCV), elevated mean corpuscular haemoglobin concentration (MCH, MCHC), a decreased red blood cell count, pallor of the skin, decreased energy and easy fatigability, shortness of breath and palpitations. The resulting anaemia of B12 deficiency, as is the case of the anaemia of folate deficiency, is a megaloblastic macrocytic anaemia. Vitamin B12 is required for the metabolism of homocysteine, proteins, fatty acids, and carbohydrates.
- Animal and epidemiologic studies have shown that folate deficiency is associated with defects of neural tube closure. Human studies have shown that folic acid, when taken by women planning to become pregnant, can greatly reduce the risk of bearing a child with spina bifida or other neural tube defects. A central feature of fetal development is widespread and sustained cell division. Folate plays a central role in the formation of nucleic acid precursors, such as thymidylic acid and purine nucleotides, which are essential for nucleic acid synthesis and cell division.
- Some studies have found that homocysteine levels in pregnant women who subsequently gave birth to children with neural tube defects, were significantly higher than those of pregnant women who gave birth to normal children. This would be expected to occur in pregnant women with low folate status. The enzyme that metabolizes homocysteine to methionine, methionine synthase, uses 5-methyltetrahydrofolate, as well as vitamin B12, as a cofactor.
- Approximately 10% of the population have a defective folate metabolizing enzyme called methylenetetrahydrofolate reductase (MTHFR). This may lead to folate deficiency and associated folate deficiency risks.
- Folic acid may have anti-atherogenic mechanisms other than that of lowering homocysteine levels. Impaired availability of endothelium-derived nitric oxide (NO), produced by the enzyme endothelial nitric oxide synthase (eNOS), has been identified as a mediator of atherosclerosis. Folic acid and 5-methyltetrahydrofolate have been demonstrated to restore impaired NO status in hypercholesterolaemic subjects.
- Epidemiologic studies have shown that diminished folate status is associated with colorectal, lung, oesophageal, brain, cervical and breast cancers. Data supporting the effect of folate status on carcinogenesis are most compelling for colorectal cancer. The mechanism of the possible anticarcinogenic activity of folate is not well understood. Folate deficiency may induce DNA hypomethylation and gene "unsilencing."
- Low concentrations of folate in the blood have been associated with poor cognitive function, dementia and Alzheimer's disease-related neurodegeneration of the brain. A recent report from the "Nun Study” showed that low serum folate was strongly associated with atrophy of the cerebral cortex. Folate deficiency has been associated with depression and other psychiatric symptoms. Consistent findings in major depression have been low plasma and low erythrocyte folate levels which have been linked to poor response to antidepressants. Subjects with low plasma folate levels responded less well to the antidepressant fluoxetine than did those with normal folate levels. A recent study reported that folic acid enhanced the antidepressant action of fluoxetine in subjects who did not appear to be folate deficient.
- Phytogenic Mineral Catalyst – Our Polyfloramin™extracts contain up to 72 trace elements for enhanced bioavailability, assimilation and synergy of the active ingredients contained in B12/Folate formula.
T J Clark’s B12/Folate formula may be beneficial in the prevention and treatment of:
- Acne, autism, Alzheimer’s disease, senility, cervical dysplasia, conditions related to the elderly, conditions related to pregnancy including pre-eclampsia, and Crohn’s disease.
- Coronary artery disease, depression, depression associated with oral contraceptives, homocysteinuria, PMS, MS, sexual vitality, ulcers (aphthous).
- Those with undiagnosed anaemia should exercise caution in the use of supplementary folic acid. Doses of folic acid greater than 100 micrograms daily may result in hematologic improvement in those with vitamin B12 deficiency.
Storage: Store below 30 C.
Dosage and Administration: 5ml once or twice daily with food.